Cannabigerol (CBG): Another promising cannabinoid?

by Duncan Fisher

October 04, 2022 - 2 min read

Cannabigerol (CBG), in its decarboxylated form, is the precursor molecule for the most abundant phytocannabinoids. Presumably because of this, and because of recent promise in medical applications for CBD, research and commercial attention is beginning to turn to CBG.Pharmacological profiling is still in its infancy; too little is known about the pharmacodynamics of cannabigerol for its release into an unregulated retail environment yet. But CBG is known to exhibit affinity and activity characteristics between Δ9-THC and CBD at the cannabinoid receptors, and it appears to have unique interactions withα-2 adrenoceptors and 5-hydroxytryptamine (5-HT1A). Preclinical data suggest that CBG could have therapeutic benefit in neurodegenerative disorders and inflammatory bowel disease, and may have antibacterial properties as well.Clinical trials are underway in psychiatry, pain, and addiction. CBG is known as well at this point to be a safe appetite stimulant in chemotherapy, and as an agent that reduces in vitro signs of pathology in colitis and colorectal cancer. 

CBG demonstrates action on the PPAR family of receptors and improves insulin sensitivity and adipogenesis, and could for this reason have an eventual role to play in the treatment of metabolic disease. It also displays antihypertensive properties atα-2 receptors. These together could be of help to patients with diabetes, who frequently have hypertension, hyperlipidemia, and insulin resistance from glucose dysregulation and vascular endothelial dysfunction. 

CBG, through the PPAR receptors, also appears to be neuroprotective. This, combined with data from other sources reporting reduction in cognitive decline in patients with neurodegenerative disease with the addition ofα-2 agonists, suggest that CBG may help in these populations too. 

CBG may even have a role as concomitant therapy in disorders of the executive function, like schizophrenia and ADHD. Two currentα-2 agonists, clonidine and guanfacine, are in use now for theirα-2-mediated action in the prefrontal cortex. Clonidine is strongly antihypertensive, and CBG is not. Guanfacine is an adjunct therapy with stimulants in ADHD because of itsα-2A receptor subtype specificity. It will be known in time whether CBG shares this specificity. 


DiolPure products contain PureForm CBD™ transformed from aromatic terpenes for pharmaceutical-grade purity. PureForm CBD™ is bioidentical to CBD extracted from hemp and cannabis, but free of any residual cannabinoids like THC or impurities or chemicals that can associate with traditional plant-derived production processes. 

The foregoing is a report on trends and developments in cannabinoid industry research. No product description herein is intended as a recommendation for diagnosis, treatment, cure or prevention of any disease or syndrome. 


Beyond glaucoma: Cannabinoids in ophthalmology

Beyond glaucoma: Cannabinoids in ophthalmology

Cannabinoids appear to have therapeutic potential in glaucoma. Beyond this, there may be further promise in ophthalmology.
Read More

December 05, 2022 1 min read

The endocannabinoid system and bone disease

The endocannabinoid system and bone disease

Stimulation of the endocannabinoid system modulates bone formation and bone resorption. There may be a role one day for targeted drugs in osteoporosis and some forms of bone cancer. 
Read More

December 02, 2022 1 min read

Sex differences, endocannabinoids, and pain

Sex differences, endocannabinoids, and pain

Sex differences in pain perception and analgesia is a burgeoning research field overall. What about cannabinoid analgesia specifically? 
Read More

December 01, 2022 2 min read

Follow us on Instagram

Net Orders Checkout

Item Price Qty Total
Subtotal $ 0.00

Shipping Address

Shipping Methods